全林虎

发布日期:2024年03月18日 13时01分58秒   阅读人数:


农学院研究生导师简介

姓名

全林虎

性别

       

民族

朝鲜族

学位

博士

职称

教授

职务


电话

18243301765

邮箱

lhquan@ybu.edu.cn

个人经历

学习经历

(1) 1999-092003-07, 延边大学, 农学, 学士

(2) 2006-092008-07, 韩国庆熙大学, 中药材料加工, 硕士

(3) 2009-032012-02, 韩国庆熙大学, 中药材料加工, 博士



工作经历

(1) 2014-082017-08,延边大学,白山生物资源与功能分子教育部重点实验室, 讲师

(2) 2017-09 至 2020-06,延边大学,长白山生物资源与功能分子教育部重点实验室, 教授

(3) 2020-07 至 今,延边大学,药学院,教授

承担主要课程

本科生课程:化学生物学药学前言讲座

研究生课程:体内药物分析,药理学进展

研究方向

肠道菌群的紊乱和肥胖以及代谢综合征有着密切的关系。肠道菌群可以作为防治肥胖的新的靶目标,通过益生元、益生菌来纠正肠道菌群紊乱,能够改善代谢综合征。课题组主要以肠道菌群为靶点,采用微生物组学和代谢组学,系统分析中药引起肠道菌群组成、功能基因、代谢产物的改变,通过机体-细胞-分子等多层次研究,明确中药、代谢产物、肠道菌群与疾病之间复杂的协同作用分子机制,建立利用肠道菌群评估植物药疗效技术方法,为中药对疾病的预防治疗提供理论依据,为以肠道菌群为靶点的新型药物的研发提供科学支撑。








科研项目


论文著作、科研成果及荣誉

主持完成了校级科研项目,州、省级科研项目多项和国家自然基金项目2项。发表论文30余篇。

1、承担科研项目情况

(1) 国家自然科学基金委员会, 地区科学基金项目, 32260026, 草苁蓉介导的肠道Lactobacillus reuteri菌通过长链脂肪酸调控糖脂代谢改善2型糖尿病的作用机制,2023-01-01 至 2026-12-31, 33万元, 在研, 主持

(2) 国家自然科学基金委员会, 地区科学基金项目, 81660643, 肠道菌群多样性与人参皂苷代谢差异相关性及其作用机制研究, 2017-01-01 至 2020-12-31, 39万元, 结题, 主持

(3) 吉林省委,吉林省“长白山人才工程青年拔尖人才”, 000007, 肠道菌群在代谢性疾病中的应用, 2022-01 至 2026-12, 25万元, 在研, 主持

(4) 吉林省科技厅, 吉林省自然科学基金, 20210101206JC, 红景天提取物介导的肠道菌群调控脂代谢的作用, 2022-01 至 2024-12, 10万元, 在研, 主持

(5) 吉林省教育厅, 吉林省教育厅科学技术研究规划项目, JJKH20210586KJ, 人参皂苷CK激活棕色脂肪改善肥胖的作用机制研究, 2021-01 至 2022-12, 2.5万元, 结题, 主持

(6) 吉林省人力资源和社会保障厅, 2020年度吉林省创新创业人才, 2020022, 人参调控糖脂代谢的研究与应用, 2020-06 至 2021-12, 20万元, 结题, 主持

(7) 中国博士后面上基金项目,2015M571376,乳酸菌中转化稀有人参皂苷C-K糖苷酶基因的筛选,2015-05至2016-12,5万元,结题,主持

(8) 吉林省择优资助博士后科研项目,014000008,生物转化稀有人参皂苷compound K关键酶基因的克隆及应用,2015-03至2016-12,3万元,结题,主持

2、代表性论文(2017至今SCI一区/二区)

(1) Lin-Hu Quan; Zhang Chuanhai; Dong Meng; Jiang Jun; Xu Hongde; Yan Chunlong; Liu Xiaomeng; Zhou Huiqiao; Zhang Hanlin; Chen Li; Zhong Fei-Liang; Luo Zhao-Bo; Lam Sin-Man; Shui Guanghou; Li Donghao; Jin Wanzhu; Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. GUT, 2020, 69(7): 1239-1247. (SCI一区TOP期刊,ESI前1%高被引论影响因子31.79)

(2) Zhao-Bo Luo; Shengzhong Han; Xi-Jun Yin; Hongye Liu; Junxia Wang; Meifu Xuan; Chunyun Hao; Danqi Wang; Yize Liu; Shuangyan Chang; Dongxu Li; Kai Gao; Huiling Li; Biaohu Quan; Lin-Hu Quan*; Jin-Dan Kang*; Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis. eLife, 2023, DOI: https://doi.org/10.7554/eLife.81858. (SCI一区TOP期刊,自然指数期刊影响因子8.7)

(3) Rongcai Ye; Chunlong Yan; Huiqiao Zhou; Chuanhai Zhang; Yuanyuan Huang; Meng Dong; Hanlin Zhang; Jun Lin; Xiaoxiao Jiang; Shouli Yuan; Li Chen; Rui Jiang; Ziyu Cheng; Kexin Zheng; Anni Yu; Qiaoli Zhang; Lin-Hu Quan*; Wanzhu Jin*; Brown adipose tissue activation with ginsenoside compound K ameliorates polycystic ovary syndrome, British Journal of Pharmacology. 2022, 179(18):4563-4574. (SCI一区TOP期刊,影响因子9.47)

(4) Yize Liu; Zheng-Yun Jin; c Jun-Xia Wang; Danqi Wang; Hongye Liu; Dongxu Li; Jun Zhu; Zhao-Bo Luo; Sheng-Zhong Han; Shuang-Yan Chang; Liu-Hui Yang; Jin-Dan Kang*; Lin-Hu Quan*; Ginsenoside Rg1 activates brown adipose tissue tocounteract obesity in high-fat diet-fed mice by regulating gut microbes and bile acid composition. Food & Function, 2023, DOI: 10.1039/d2fo03142f. (SCI一区TOP期刊,影响因子6.317)

(5) Sheng-Zhong Han; Kai Gao; Shuang-Yan Chang; Hak-Myong Choe; Hyo-Jin Paek; Biao-Hu Quan; Xin-Yue Liu; Liu-Hui Yang; Si-Tong Lv; Xi-Jun Yin; Lin-Hu Quan*; Jin-Dan Kang*; miR-455-3p Is Negatively Regulated by Myostatin in Skeletal Muscle and Promotes Myoblast Differentiation. Journal of Agricultural and Food Chemistry, 2022, 70(33):10121-10133. (SCI一区TOP期刊,影响因子5.89)

(6) Wei-Wei Dong; Fang-Ling Xuan; Fei-Liang Zhong; Jun Jiang; Songquan Wu; Donghao Li; Lin-Hu Quan*; Comparative Analysis of the Rats' Gut Microbiota Composition in Animals with Different Ginsenosides Metabolizing Activity. Journal of Agricultural and Food Chemistry, 2017, 65(2): 327-337. (SCI一区TOP期刊,影响因子5.89)

(7) Wei-Wei Dong; Jinhua Zhao; Fei-Liang Zhong; Wen-Jing Zhu; Jun Jiang; Songquan Wu; Deok-Chun Yang; Donghao Li; Lin-Hu Quan*; Biotransformation of Panax ginseng extract by rat intestinal microflora: identification and quantification of metabolites using liquid chromatography-tandem mass spectrometryx, Journal of Ginseng Research, 2017, 41(4):540-547. (SCI一区TOP期刊,影响因子5.73)

(8) Xiong-Zhe Han, Rui Ma, Qi Chen, Xin Jin, Yuan-Zhe Jin, Ren-Bo An, Xuan-Mei Piao, Mei-Lan Lian, Lin-Hu Quan*, Jun Jiang; Anti-inflammatory action of Athyrium multidentatum extract suppresses the LPS-induced TLR4 signaling pathway. Journal of Ethnopharmacology, 2018, 217:220-227. (SCITOP期刊,影响因子5.19)

(9) Hongye Liu; Zhi-Yong An; Zhou-Yan Li; Liu-Hui Yang; Xiu-Li Zhang; Yan-Tong Lv; Xi-Jun Yin; Lin-Hu Quan*; Jin-Dan Kang*; The ginsenoside Rh2 protects porcine oocytes against aging and oxidative stress by regulating SIRT1 expression and mitochondrial activity. Theriogenology, 2023, 200:125-135. (SCITOP期刊,影响因子2.92)

(10) Danqi Wang; Jun-Xia Wang; Chunri Yan; Yize Liu; Hongye Liu; Dongxu Li; Jun Zhu; Zhao-Bo Luo; Sheng-Zhong Han; Zheng-Yun Jin; Shuang-Yan Chang; Liu-Hui Yang; Jin-Dan Kang*; Lin-Hu Quan*; Gastrodia elata Blume extract improves high-fat diet-induced type 2 diabetes by regulating gut microbiota and bile acid profile. Frontiers in Microbiology, 2022, 13:1091712. (SCITOP期刊,影响因子6.06)

(11) Shuang-Yan Chang; Sheng-Zhong Han; Hak-Myong Choe; Kai Gao; Zheng-Yun Jin; Xin-Yue Liu; Liu-Hui Yang; Si-Tong Lv; Xi-Jun Yin; Lin-Hu Quan*; Jin-Dan Kang*; miR-320 regulates myogenesis by targeting growth factor receptor-bound protein-2 and ameliorates myotubes atrophy. Int J Biochem Cell Biol, 2022, 147:106212. (SCI二区,影响因子5.65)


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